Sarah Ayling - Group Leader
Sarah leads the Computational Genomics Group and joined TGAC in December 2011. The group is focused on genome assembly and variant calling, and works with crop plants, animal and viral data.
Her main interest is in variant detection and associations between genotype and phenotype for use in plant breeding, including the use of crop wild relatives. In addition, she is interested in visualisation and querying of variation data for use by geneticists and breeders, particularly with the challenges posed by polyploid genomes.
Prior to joining TGAC, she was the lead bioinformatician at CIAT, Colombia (Centro Internacional de Agricultura Tropical) working with the bean, cassava, rice and tropical forage programs.
She studied Biological Science at UMIST, and has a PhD in Bioinformatics from the University of Manchester where she worked on intraspecific phylogenetic network analyses. She also ran and developed the Ensembl genome annotation pipeline as part of the Ensembl genebuild team at the Wellcome Trust Sanger Institute, Cambridge.
The International Barley Genome Sequencing Consortium (2012) A physical, genetic and functional sequence assembly of the barley genome. Nature doi:10.1038/nature11543
Ayling S., et al. (2012) Information resources for cassava research and breeding. Tropical Plant Biology 5(1): 140-151
Utsumi Y., et al. (2012) RIKEN Cassava Initiative: Establishment of a Cassava Functional Genomics Platform. Tropical Plant Biology 5(1): 110-116
Blair M.W., et al. (2011) Construction and EST sequencing of full-length, drought stress cDNA libraries for common beans (Phaseolus vulgaris L.). BMC Plant Biology 11: 171
Hubbard T.J.P., et al. (2009) Ensembl 2009. Nucleic Acids Research, 37: D690-D697
Pruitt K.D., et al. (2009) The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes. Genome Research, 19(8): 1506
Ayling S.C. and Brown T.A. (2008) Novel methodology for construction and pruning of quasi-median networks. BMC Bioinformatics 9: 115
Flicek P., et al. (2008) Ensembl 2008. Nucleic Acids Research, 36:D707-D714
Hubbard T.J.P., et al. (2007) Ensembl 2007. Nucleic Acids Research, 35: D610-D617