Lisa Crossman - Project Leader
The Microbial Genomes group study DNA sequence information from a wide range of microbes from diverse habitats. We have strong collaborative links with the Institute of Food Research, University of East Anglia and John Innes Centre, Norwich as well as links with the Health Protection Agency, Colindale, Universities of Nottingham and Bristol and as far afield as University of Maryland, USA and Texas A&M University, Florida, USA.
Lisa is Microbial Genomes Project Leader with a strong background in both Laboratory-based and Bioinformatics research.
She has a Microbiology degree from the University of Bristol, an MSc in Molecular Genetics form the University of Leicester and a PhD from the University of East Anglia, Norwich. Lisa joined TGAC in early 2010 and took up her current post in 2011. She was elected to Honorary Lectureship at UEA in 2010.
Lisa has substantial experience in genome annotation and analysis, having previously worked at the Pathogen Sequencing Unit at the Wellcome Trust Sanger Institute, Cambridge, where she was involved in many key prokaryotic sequencing projects in particular heading up Rhizobium leguminosarum and Stenotrophomonas maltophilia genome projects
A small predatory core genome in the divergent marine Bacteriovorax marinus SJ and the terrestrial Bdellovibrio bacteriovorus. Crossman LC et al., 2012. ISME J. (Nature group), doi:10.1038/ismej.2012.90
Large scale expansion of mobile elements in specific hotspot regions of the German Outbreak Escherichia coli O104:H4. Crossman LC. 2011. Nature Precedings: http://hdl.handle.et/10101/npre.2011.6466.1
Draft Genome Sequence of Streptomyces strain S4, a symbiont of the leaf-cutting ant Acromyrmex octospinosus. Seipke R, Crossman L et al. J. Bacteriol. 2011. 193(16) 4270-1.
Genome Sequence of the vertebrate gut symbiont Lactobacillus reuteri ATCC 53608. Heavens D, Tailford LE, Crossman L. et al. J. Bacteriol. 2011 193(15): 4015-6.
Complete Genome Sequence of the proteolytic Clostridium botulinum type A5 (B3') strain H04402 065. Carter AT, Pearson BM, Crossman LC et al. J. Bacteriol. 2011. 193(9):2351-2
Previous Selected Publications:
A commensal gone bad: complete genome sequence of the prototypical Escherichia coli strain H10407. Crossman LC et al. J. Bacteriol. 2010. 192(21):5822-31.
Comparative genomics of the emerging human pathogen Photorahabdus asymbiotica with the insect pathogen Photorhabdus luminescens. BMC Genomics. 2009. 7, 10:302.
The versatility and adaptation of bacteria from the genus Stenotrophomonas. Ryan RP, Monchy S., Cardinale M, Taghavi S, Crossman L et al. 2009. Nat Rev Microbiol 7(7):514-25.
A common genomic framework for a diverse assembly of plasmids in the symbiotic nitrogen fixing bacteria. Crossman LC et al. PLoS One. 2008. 2,3(7):e2567.
The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Crossman LC et al. Genome Biol. 2008 17,9(4):R74
Scaling up next generation sequencing in the hunt for new antibiotics. SMi Pharma, London, 2012.
Crowdsourcing the German outbreak E.coli. International Conference on Genomics (ICG-Europe), Copenhagen, DK, 2012.
Cold beansprouts, cucumbers, crowds and coli; the story of an outbreak, Norwich Science Café, Norwich, 2012
Strengths and limitations of next generation sequencing and how do we future-proof this approach, Epidemiology meeting, London, UK, 2012
Crowdsourcing the German outbreak E.coli. Departmental seminar, University of Nottingham, Sutton Bonington, UK, 2012.
Podcast on German outbreak E.coli, Society for General Microbiology, York, 2011