The Genome Analysis Centre receives strategic funding from the BBSRC
The Microbial Genomes Group, led by Lisa Crossman, analyse next generation whole genome sequence information for a large variety of bacteria and small eukaryotes with the aim of annotating and visualising comparative genomics data.
We work closely with other groups at TGAC to improve on assemblies and capitalise on the core bioinformatics facilities.
Current research interests include Molecular Biodiversity, Comparative Genomics and Phylogenetics.
Our projects range from single sequences of high molecular biodiversity to deep resequencing projects with small specific areas of diversity. Genome sequence analysis can be extended by transcriptome data, which will decisively determine transcription start sites as well as providing an excellent expression resource.
We use comparisons between environmental and clinically isolated organisms to identify important genetic regions for each type of isolate. Using phylogenetic analysis we aim to cluster groups, creating understanding from their taxonomic positioning and tracking horizontal gene flow.
Key activities include: