TGAC Capacity and Capability Challenge Programme

CCC Projects

Round 1

Project

Core area

Core technology

Summary of new Brassica projects proposed by UK-China Brassica genome sequencing project

Crop genomics

Transcriptomics

Sequencing the transcriptome of hexaploid wheat

Crop genomics

Transcriptomics

End sequencing BAC library for chromosome 3DL of wheat

Crop genomics

de novo

The impact of introducing a barcoding strategy in short RNA profiling projects

Crop genomics

small RNA

Quatifying diversity, distribution, and community structure within the cryptozoa with high throughput sequencing

Microbial genomes

Amplicon

Ant pharming – the search for new natural products

Microbial genomes

de novo

cDNA sequencing of multiple choanoflagellate species

Microbial genomes

Transcriptomics

Generation of 454 sequence resources for diploid oat

Crop genomics

Transcriptomics

Castor bean mRNA sequencing

Crop genomics

Transcriptomics

Use of Next Gen sequencing for RNA-seq analysis of the Campylobacter transcriptome

Microbial genomes

Transcriptomics

Genome sequence of Lactobacillus reuteri

Microbial genomes

de novo

Identification of developmentally expressed small RNAs (miRNAs, piRNAs and other small RNAs) in Xenopus tropicalis and Xenopus laevis

Genomics for animal systems

small RNA

Round 2

Project

Core area

Core technology

Sequencing and diversity analysis in red clover (Trifolium pratense)

Crop genomics

de novo

Total genome sequencing of the plant pathogenic fungus Colletotrichum gloeosporioides

Microbial genomes

de novo

Sequencing the genome of a key food species, the Common Carp, Cyprinus carpio

Genomics for animal systems

de novo

Digital transcriptomics to understand the evolution of flower size and the selfing syndrome

Crop genomics

Transcriptomics

Sequencing the genome of an organism of unique interest for research on ageing: Heterocephalus glaber, the naked mole-rat

Genomics for animal systems

de novo

Comparative analysis of the metatranscriptome of the rhizosphere microbial community of pea, oat and wheat

Microbial genomes

Transcriptomics

Transcriptome analysis to determine the genetic basis of the high sugar trait in perennial ryegrass (Lolium perenne)

Crop genomics

Transcriptomics

Transcriptome analysis of mice under different energy balance regimes: a platform comparison

Genomics for animal systems

Transcriptomics

Round 3

Project

Core area

Core technology

Genome sequence and annotation of the medicinal maggot Lucilla sericata 

Genomics for animal systems

de novo

Natural history of SIV infection of chimpanzees

Viral genomes

Re-sequencing

Novel viral discovery, gene expression analysis and identification of expressed endogenous retroviral-like sequences in canine hepatitis

Viral genomes

Transcriptomics

Obtaining the genome seqence of the economically important UK pest and plant virus vector, the aphid Myzus periscae Sulz.

Genomics for animal systems

de novo

RNAseq transcriptome analysis of adaptively divergent phenotypes in Passion-flower butterflies (Genus: Heliconius)

Genomics for animal systems

Transcriptomics

Yeast genome re-sequencing to enhance national capability in microbial biotechnology and aid the development of novel bioinformatics

Microbial genomes

Re-sequencing

Development of a pipeline for reliable, quantitative and high-throughput analysis of crop epigenomes

Crop genomics

Epigenome / regulome

Round 4

Project

Core area

Core technology

Genetic diversity in fission yeast as a basis to analyze complex relationships between genotype, phenotype and environment

Microbial genomes

Re-sequencing

Analysis of chloroplast genomes using high-throughput sequencing methods

Crop genomics

Re-sequencing

Chordate muscle transcriptomics in response to feeding

Genomics for animal systems

Transcriptomics

Optimisation of resequencing for Single Nucleotide Polymorphism analysis of AT-rich bacterial pathogens using Listeria monocytogenes as a model

Microbial genomes

Re-sequencing

The transcriptomic basis of shorebird behavioural dimorphism

Genomics for animal systems

Transcriptomics

Comparative genomics of nematode parasitic bacteria belonging to Pasteuria spp.

Microbial genomes

de novo

Rumen microbial utilisation of plant material: a functional core at the plant-microbe interface?

Microbial genomes

Transcriptomics

Capture sequencing of a 2 Mb locus associated with canine retinal degeneration mapped by GWAS.

Genomics for animal systems

Target enrichment

Mutation discovery through TILLING-by-sequencing

Crop genomics

Amplicon / reduce representation

Overcoming a lack of recombination and/or Identity-by-descent in positional cloning projects

Crop genomics

Re-sequencing

Round 5

Project

Core area

Core technology

Transcriptome analysis of the retina to identify stop and go signals for form-deprivation myopia (FDM) in chickens

Genomics for animal systems

Transcriptomics

Exploiting metabolic diversity in the Brassicaceae: underpinning methods

Crop genomics

Transcriptomics

Development of an equine herpesvirus-1 (EHV-1) genome sequencing pipeline

Viral genomes

Re-sequencing

Differential expression of parental alleles in the progeny of an interspecific cross in the energy crop Miscanthus

Crop genomics

Transcriptomics

Evolution of organisms associated with methanogenic communities during the initiation of bioenergy fermentation

Microbial genomes

Amplicon / reduce representation

Rapid mapping of gene-trap insertions in the human genome to facilitate novel haploid genetic screens

Genomics for animal systems

Re-sequencing

Intra- and inter-host evolutionary dynamics of mammalian influenza viruses

Viral genomes

Re-sequencing

SUGA: Sugar beet Genome Analysis for novel traits in arable crops

Crop genomics

de novo

The MHC class II haplotype determines susceptibility to superantigen-dependent streptococcal disease in the horse

Genomics for animal systems

Target enrichment

Epigenetic mechanisms of organismal adaptation to environmental change

Microbial genomes

Epigenome / regulome

Establishment of next-gen sequencing method for epigenetic methylation markers of DNA binding and transcriptional regulation

Microbial genomes

Epigenome / regulome

Genome-wide localization of the histone H2A.Z variant in Saccharomyces cerevisiae strains with a compromised unfolded protein response (UPR)

Microbial genomes

Epigenome / regulome

Assessing the Impact of the Influenza Antiviral Tamiflu on Freshwater Microbial Biofilms

Microbial genomes

Amplicon / reduce representation

Transcriptional Regulation of Urothelial Cytodifferentiation

Genomics for animal systems

Epigenome / regulome

Comparative digital transcriptional profiling of canine and human uveal melanomas

Genomics for animal systems

Transcriptomics

Generating a draft genome sequence for Cardamine hirsuta and SNP discovery/mapping

Crop genomics

de novo

The genome of the arbuscular mycorrhizal fungus Glomus intraradices

Microbial genomes

de novo

Round 6

Project

Core area

Core technology

Illumina Transcriptomic Sequencing of Complex Microbial Communities

Microbial genomes
Transcriptomics

Streptomyces dRNA seq: an emerging technique for mapping transcripts and small RNAs at the genome level

Microbial genomes
small RNA

Dynamic alternative splicing in barley

Crop genomics
Transcriptomics

The role of miRNAs in potato tuber formation

Crop genomics
small RNA

Genome-wide comparison of European (Apis mellifera) and Asian (A. cerana) honeybee to investigate parasite-mediated selection

Genomics for animal systems
RAD-seq

Evolution and interplay between the interactomes of human genes responding to the cytokines TNFa and TGFb.

Genomics for animal systems
Epigenome / regulome

Evaluation of cDNA RAD to directly detect transcriptional variation in two non-model organisms, the snail Lymnaea stagnalis and the ladybird Harmonia axyridis

Genomics for animal systems
RAD-seq

Identification of EHV-1 miRNAs expressed in lytic and latent infection

Viral genomes
small RNA

Global transcriptomic analysis to evaluate the role of Vpu in SIV pathogenesis in the natural host

Viral genomes
Transcriptomics

Small RNA identification and comparative transcriptome analysis in Mycobacterium bovis field isolates by RNA-seq.

Microbial genomes
small RNA

Investigating the molecular basis for mucin glycan degradation in human commensal bacteria

Microbial genomes
Transcriptomics

Early-lethal mutant identification through deep-sequencing of wild-type sibs

Crop genomics
 

Whole transcriptome sequencing of Ligusticum grayi (Apiaceae): a medicinal plant used for digestive ailments

Crop genomics
Transcriptomics

Colonisation of roots by plant growth promoting rhizosphere bacteria

Microbial genomes
Transcriptomics

Identification of social and individually-beneficial virulence genes via insertion site sequencing following a high-throughput screen of transposon mutants

Microbial genomes
Amplicon / reduce representation

Do hosts and symbionts conspire to eliminate exogenous bacteria during metamorphosis?

Microbial genomes
Transcriptomics

Analysis of the quasi-species nature of Bovine viral diarrhea virus infection

Viral genomes
Re-sequencing

Arabidopsis Thermosensitivity Hi-C Pilot Study

Crop genomics
Epigenome / regulome

Development of genomic tools to assist isolation of novel disease resistance genes from wheat relatives for deployment in wheat

Crop genomics
Amplicon / reduce representation