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TGAC Fellowship Programme in Computational Biology

TGAC Fellowships


The Genome Analysis Centre (TGAC) is pleased to announce the launch of a new, five-year, fellowship programme in Computational Biology. The programme is aimed at outstanding early-career computational biologists and bioinformaticians who wish to establish themselves as scientific leaders within a dynamic research environment. Appointments can be made at any level dependent on the candidate’s experience. Candidates will also receive a significant research support grant.

We are seeking candidates with an excellent track record whose interests cover areas of strategic and scientific interest to TGAC, our partners on the Norwich Research Park (NRP) and the BBSRC (please refer to

The Norwich Research Park is a research campus partnership comprised of TGAC, the John Innes Centre, the Institute of Food Research, The Sainsbury Laboratory, the University of East Anglia and Norfolk and Norwich University Hospital. The NRP aims to deliver solutions to the global challenges of healthy ageing, food and energy security, sustainability and environmental change. It is an international centre of excellence in life and environmental sciences research with world-class expertise in the research and development pipeline from genomics and data analytics, global geochemical cycles and crop biology, through to food, health and human nutrition.  This provides an excellent environment for the development of synergistic research. The successful candidates will be required to develop a research project in collaboration with other researchers within the park. In particular, we encourage proposals that address biological challenges relevant to the NRP that may necessitate:

  • New approaches to the analysis and interpretation of research data at scale such as: data visualisation, digital simulations, data integration and the handling of complex datasets arising from high throughput technologies.
  • Methods and strategies to address challenges arising in applying next generation sequencing to genomics, transcriptomics, metagenomics and epigenomics.
  • Development of novel algorithms for the fast analysis of streaming data, in particular in the context of applications to rapid diagnostics and surveillance.


Potential applicants to this scheme are encouraged to initially contact before submitting a full application. The call for Fellowship applications will remain open until all positions have been filled, however applications will start to be considered from 16th May 2016.

Current Opportunities

Fellowships at TGAC

Diane SaundersDiane Saunders

As a research fellow at The Genome Analysis Centre, working in partnership with the John Innes Centre, my group focuses on applying a multidisciplinary approach to the study of plant pathogen interactions, integrating molecular genetics, microbiology, plant pathology, population genetics, genomics and data mining to improve our understanding of the molecular mechanisms at the plant pathogen interface.

We are especially interested in how pathogens adapt to changing environments such as new host genotypes. This can be studied in depth by characterizing and analyzing the genes encoding pathogen effector repertoires. Plant pathogens deliver effector proteins to their hosts to reprogram plant defense circuitry and enable parasitic colonization. On certain plant genotypes, effectors that act within the host cell can be recognized by immune receptors, encoded by resistance genes, which initiate defence responses. Increasing our understanding of the population dynamics and the evolution rate of (re-) emerging plant pathogens may enhance the deployment of effective resistant genotypes that fully embody the pathogens’ diversity. Our research is focused on studying (re-) emerging plant pathogens that pose a significant threat to UK agriculture. For instance, we have numerous projects studying the wheat yellow rust pathogen, Puccinia striiformis f. sp tritici that is a substantial threat to wheat production worldwide and more recently re-emerged as a major constraint on UK agriculture.

Tamas KorcsmarosTamas Korcsmaros

I study systems regulation of autophagy in humans. Autophagy is a membrane trafficking pathway that generates autophagosomes which deliver cytosol to lysosomes for degradation. Autophagy provides a powerful means of removing intracellular pathogens and is an important arm of innate immunity to infection.

In the gut, host-pathogen interaction is important for intestinal homeostasis; malfunction of autophagy is related to inflammatory bowel disease (IBD) and cancer progression. A better understanding of the effect of particular bacterial species on the regulation of human intestinal autophagy could help to identify prognosis markers for IBD and colon cancer.

By applying network methodologies my research aims to investigate how foodborne pathogens or probiotics affect autophagy, and how antibiotics treatments could influence intestinal autophagic activity by changing the gut microbiota.

Appointments can be made at any level dependent on the candidate’s experience. Candidates will also receive a significant research support grant.
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