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Building Excellence in
Genomics and Computational Bioscience
TGAC projects are designed around our expertise in identifying and addressing the question to be answered through sequencing
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TGAC Capacity and Capability Challenge Programme

CCC Projects

Round 1

Project

Core area

Core technology

1. Summary of new Brassica projects proposed by UK-China Brassica genome sequencing project

Crop genomics

Transcriptomics

2. Sequencing the transcriptome of hexaploid wheat

Crop genomics

Transcriptomics

3. End sequencing BAC library for chromosome 3DL of wheat

Crop genomics

de novo

4. The impact of introducing a barcoding strategy in short RNA profiling projects

Crop genomics

small RNA

5. Quatifying diversity, distribution, and community structure within the cryptozoa with high throughput sequencing

Microbial genomes

Amplicon

6. Ant pharming – the search for new natural products

Microbial genomes

de novo

7. cDNA sequencing of multiple choanoflagellate species

Microbial genomes

Transcriptomics

8. Generation of 454 sequence resources for diploid oat

Crop genomics

Transcriptomics

9. Castor bean mRNA sequencing

Crop genomics

Transcriptomics

10. Use of Next Gen sequencing for RNA-seq analysis of the Campylobacter transcriptome

Microbial genomes

Transcriptomics

11. Genome sequence of Lactobacillus reuteri

Microbial genomes

de novo

12. Identification of developmentally expressed small RNAs (miRNAs, piRNAs and other small RNAs) in Xenopus tropicalis and Xenopus laevis

Genomics for animal systems

small RNA

Round 2

Project

Core area

Core technology

1. Sequencing and diversity analysis in red clover (Trifolium pratense)

Crop genomics

de novo

2. Total genome sequencing of the plant pathogenic fungus Colletotrichum gloeosporioides

Microbial genomes

de novo

3. Sequencing the genome of a key food species, the Common Carp, Cyprinus carpio

Genomics for animal systems

de novo

4. Digital transcriptomics to understand the evolution of flower size and the selfing syndrome

Crop genomics

Transcriptomics

5. Sequencing the genome of an organism of unique interest for research on ageing: Heterocephalus glaber, the naked mole-rat

Genomics for animal systems

de novo

6. Comparative analysis of the metatranscriptome of the rhizosphere microbial community of pea, oat and wheat

Microbial genomes

Transcriptomics

7. Transcriptome analysis to determine the genetic basis of the high sugar trait in perennial ryegrass (Lolium perenne)

Crop genomics

Transcriptomics

8. Transcriptome analysis of mice under different energy balance regimes: a platform comparison

Genomics for animal systems

Transcriptomics

Round 3

Project

Core area

Core technology

1. Genome sequence and annotation of the medicinal maggot Lucilla sericata

Genomics for animal systems

de novo

2. Natural history of SIV infection of chimpanzees

Viral genomes

Re-sequencing

3. Novel viral discovery, gene expression analysis and identification of expressed endogenous retroviral-like sequences in canine hepatitis

Viral genomes

Transcriptomics

4. Obtaining the genome seqence of the economically important UK pest and plant virus vector, the aphid Myzus periscae Sulz.

Genomics for animal systems

de novo

5. RNAseq transcriptome analysis of adaptively divergent phenotypes in Passion-flower butterflies (Genus: Heliconius)

Genomics for animal systems

Transcriptomics

6. Yeast genome re-sequencing to enhance national capability in microbial biotechnology and aid the development of novel bioinformatics

Microbial genomes

Re-sequencing

7. Development of a pipeline for reliable, quantitative and high-throughput analysis of crop epigenomes

Crop genomics

Epigenome / regulome

Round 4

Project

Core area

Core technology

1. Genetic diversity in fission yeast as a basis to analyze complex relationships between genotype, phenotype and environment

Microbial genomes

Re-sequencing

2. Analysis of chloroplast genomes using high-throughput sequencing methods

Crop genomics

Re-sequencing

3. Chordate muscle transcriptomics in response to feeding

Genomics for animal systems

Transcriptomics

4. Optimisation of resequencing for Single Nucleotide Polymorphism analysis of AT-rich bacterial pathogens using Listeria monocytogenes as a model

Microbial genomes

Re-sequencing

5. The transcriptomic basis of shorebird behavioural dimorphism

Genomics for animal systems

Transcriptomics

6. Comparative genomics of nematode parasitic bacteria belonging to Pasteuria spp.

Microbial genomes

de novo

7. Rumen microbial utilisation of plant material: a functional core at the plant-microbe interface?

Microbial genomes

Transcriptomics

8. Capture sequencing of a 2 Mb locus associated with canine retinal degeneration mapped by GWAS.

Genomics for animal systems

Target enrichment

9. Mutation discovery through TILLING-by-sequencing

Crop genomics

Amplicon / reduce representation

10. Overcoming a lack of recombination and/or Identity-by-descent in positional cloning projects

Crop genomics

Re-sequencing

Round 5

Project

Core area

Core technology

1. Transcriptome analysis of the retina to identify stop and go signals for form-deprivation myopia (FDM) in chickens

Genomics for animal systems

Transcriptomics

2. Exploiting metabolic diversity in the Brassicaceae: underpinning methods

Crop genomics

Transcriptomics

3. Development of an equine herpesvirus-1 (EHV-1) genome sequencing pipeline

Viral genomes

Re-sequencing

4. Differential expression of parental alleles in the progeny of an interspecific cross in the energy crop Miscanthus

Crop genomics

Transcriptomics

5. Evolution of organisms associated with methanogenic communities during the initiation of bioenergy fermentation

Microbial genomes

Amplicon / reduce representation

6. Rapid mapping of gene-trap insertions in the human genome to facilitate novel haploid genetic screens

Genomics for animal systems

Re-sequencing

7. Intra- and inter-host evolutionary dynamics of mammalian influenza viruses

Viral genomes

Re-sequencing

8. SUGA: Sugar beet Genome Analysis for novel traits in arable crops

Crop genomics

de novo

9. The MHC class II haplotype determines susceptibility to superantigen-dependent streptococcal disease in the horse

Genomics for animal systems

Target enrichment

10. Epigenetic mechanisms of organismal adaptation to environmental change

Microbial genomes

Epigenome / regulome

11. Genome-wide localization of the histone H2A.Z variant in Saccharomyces cerevisiae strains with a compromised unfolded protein response (UPR)

Microbial genomes

Epigenome / regulome

12.Assessing the Impact of the Influenza Antiviral Tamiflu on Freshwater Microbial Biofilms

Microbial genomes

Amplicon / reduce representation

13. Transcriptional Regulation of Urothelial Cytodifferentiation

Genomics for animal systems

Epigenome / regulome

14. Comparative digital transcriptional profiling of canine and human uveal melanomas

Genomics for animal systems

Transcriptomics

15. The genome of the arbuscular mycorrhizal fungus Glomus intraradices

Microbial genomes

de novo

Round 6

Project

Core area

Core technology

1. Illumina Transcriptomic Sequencing of Complex Microbial Communities

Microbial genomes
Transcriptomics

2. Streptomyces dRNA seq: an emerging technique for mapping transcripts and small RNAs at the genome level

Microbial genomes
small RNA

3. Dynamic alternative splicing in barley

Crop genomics
Transcriptomics

4. The role of miRNAs in potato tuber formation

Crop genomics
small RNA

5. Genome-wide comparison of European (Apis mellifera) and Asian (A. cerana) honeybee to investigate parasite-mediated selection

Genomics for animal systems
RAD-seq

6. Evolution and interplay between the interactomes of human genes responding to the cytokines TNFa and TGFb.

Genomics for animal systems
Epigenome / regulome

7. Evaluation of cDNA RAD to directly detect transcriptional variation in two non-model organisms, the snail Lymnaea stagnalis and the ladybird Harmonia axyridis

Genomics for animal systems
RAD-seq

8. Identification of EHV-1 miRNAs expressed in lytic and latent infection

Viral genomes
small RNA

9. Global transcriptomic analysis to evaluate the role of Vpu in SIV pathogenesis in the natural host

Viral genomes
Transcriptomics

10. Small RNA identification and comparative transcriptome analysis in Mycobacterium bovis field isolates by RNA-seq.

Microbial genomes
small RNA

11. Investigating the molecular basis for mucin glycan degradation in human commensal bacteria

Microbial genomes
Transcriptomics

12. Early-lethal mutant identification through deep-sequencing of wild-type sibs

Crop genomics

13. Whole transcriptome sequencing of Ligusticum grayi (Apiaceae): a medicinal plant used for digestive ailments

Crop genomics
Transcriptomics

14. Colonisation of roots by plant growth promoting rhizosphere bacteria

Microbial genomes
Transcriptomics

15. Identification of social and individually-beneficial virulence genes via insertion site sequencing following a high-throughput screen of transposon mutants

Microbial genomes
Amplicon / reduce representation

16. Do hosts and symbionts conspire to eliminate exogenous bacteria during metamorphosis?

Microbial genomes
Transcriptomics

17. Analysis of the quasi-species nature of Bovine viral diarrhea virus infection

Viral genomes
Re-sequencing

18. Arabidopsis Thermosensitivity Hi-C Pilot Study

Crop genomics
Epigenome / regulome

19. Development of genomic tools to assist isolation of novel disease resistance genes from wheat relatives for deployment in wheat

Crop genomics
Amplicon / reduce representation
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